Therefore, hypoxemia due to V/Q mismatch, diffusion limitation, and shunt will have widened gradient, whereas hypoxemia due to hypoventilation would have normal gradient. Pathology of the alveolocapillary unit widens the gradient. The A-a oxygen gradient indicates the integrity of the alveolocapillary membrane and effectiveness of gas exchange. If by some off-chance you’re attempting to run an LOD build to start off, I’d encourage you to get a farming set first to farm the ancients for that build first instead of trying to use that build to farm the ancients for that build.It is the difference between alveolar oxygen level (PAO 2) and arterial oxygen level (PaO 2) and is represented by the following equation: Alveolar to arterial (A-a) oxygen gradient = PAO 2 – PaO 2. Once you start pounding out GR100’s you’ll get 12 legendaries per 1-3 minute run and see the odds in action. Even if it rolls ancient that doesn’t automatically make it better than a well rolled non-ancient and of course by extension, a primal ancient is frequently NOT better than a non-primal regular ancient.

This is not equivalent to saying 1 in every 10 legendary items will roll as ancient. The math on legendary items is that if an item drops and rolls as a legendary item, that single roll has a 10% chance at being both legendary and ancient. You can complete T16 (GR75)-GR100 with even just non ancient items with the right full set for most classes right now. You should be working on evening out your gear sets, getting full builds, and getting the gear pieces you need rather than ancients at this point. For reference, at the start of the season, people are at your level and point of farming by the end of night 1 of the season.

Par for course at this stage in the season. Paragon 400 hasn’t completed gr70 complaining about loot drops.

Diablo 3 primal ancient drop rate